The Substance - watch online: streaming, buy or rent
We couldn’t find any streaming options in South Africa, but The Substance is available in Argentina and 38 other countries on MUBI, HBO Max, and 53 other services.
The Substance (2024)
81%
7.2 (443k)2h 21min
Watch Now
The Substance is not available for streaming in South Africa. After checking 1,585 streaming services, we found the title in 39 other countries.
United Kingdom 
Something wrong? Let us know!
Synopsis
A fading celebrity takes a black-market drug: a cell-replicating substance that helps her create a younger, better version of herself.
Videos: Trailers, Teasers, Featurettes
Cast
Demi Moore
Elisabeth
Margaret Qualley
Sue
Dennis Quaid
Harvey
Gore Abrams
Oliver
Oscar Lesage
Troy
Christian Erickson
Man at Diner
Robin Greer
Male Nurse
Tom Morton
Doctor
Hugo Diego Garcia
Diego - Boyfriend
Daniel Knight
Casting Director
Jonathon Carley
Assistant Casting Director
Vincent Colombe
Man in Suit #1 - Harvey's Office
Lennard Ridsdale
Man in Suit #3
Jordan Ford Silver
Assistant Director - Pump It Up Show
Oscar Salem
2nd Assistant Director - Pump It Up Show
Viviane Bossina
Sue's Assistant
Matthew Luret
Floor Runner
Jana Bittnerová
Maria
Olivier Raynal
Alan - 2nd Agent
Tiffany Hofstetter
Stylist
